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KMID : 0191120200350150130
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Journal of Korean Medical Science
2020 Volume.35 No. 15 p.130 ~ p.130
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Therapeutic Effects of Mesenchymal Stem Cells on a Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Model
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Park So-Young
Oh In-Young
Kim Jung-Hyun
Kim Hyo-Jung
Seo Bo-Mi
Kwon Oh-Young
Song Woo-Jung
Kwon Hyouk-Soo
Cho You-Sook
Moon Hee-Bom
Kim Tae-Bum
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Abstract
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Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are the most severe cutaneous drug hypersensitivity reactions, which are unpredictable adverse drug reactions. SJS/TEN is associated with significant mortality and morbidity; however, effective treatment is difficult. Mesenchymal stem cells (MSCs) are well-known for their anti-inflammatory and tissue regeneration properties. The purpose of the present study was to verify whether MSCs could be applied for the treatment of SJS/TEN. We developed an SJS/TEN mouse model using peripheral blood mononuclear cells from a lamotrigine-induced SJS patient. MSCs were injected into the model to verify the treatment effect. In SJS model mice treated with MSCs, ocular damage rarely occurred, and apoptosis rate was significantly lower. We demonstrated a therapeutic effect of MSCs on SJS/TEN, with these cells presenting a potential novel therapy for the management of this disorder.
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KEYWORD
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Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Mesenchymal Stem Cells, Drug Hypersensitivity, Adverse Drug Reaction
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